Chemotherapy was potentiated by E7449 and single agent experienced significant antitumor activity in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell traces, probable as a result of TNKS inhibition. Consistent with this possibility, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and substantially altered https://davida974sxb8.blogspothub.com/profile